Endocrine Abstracts

Introduction: Pituitary tumours may interfere with fertility and pregnancy may be uncommon in these cases, but some patients can conceive spontaneous. Also in pregnancy, due to the physiologic changes of the pituitary gland, gradual volume increase and cellular hyperplasia that target hormonal secretion, the evaluation of the pituitary function is very complex.Clinical cases: We present 5 cases of female patients (24 – 35 years old) that were diagn...

Introduction: Known as a potent anabolic drug, teriparatide has a stimulating effect on bone formation, increasing bone mineral density (BMD) and reducing fracture risk.Methods: 11 Caucasian women (mean age 66 years old) with severe osteoporosis treated with recombinant human parathyroid hormone (1–34) – teriparatide (Forsteo) 20 micrograms daily for 24 months were added to the study.BMD at lumbar spine, total hip and f...

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that is caused by mutations of genes involved with adrenal steroidogenesis. The mutations mostly occur in the 21-hydroxylase gene and rarely in the 3β-hydroxysteroid dehydrogenase gene or 11β-hydroxylase genes. Our aim is to present a series of 3 cases of patients with late onset CAH, probably due to 21-hydroxylase deficiency, after 50 years of age.Case series...

Background: Medullary thyroid carcinoma (MTC) is a rare thyroid neoplasm with a high degree of malignancy derived from the parafollicular calcitonin-secreting cells. This carcinoma may occur sporadically in about 80% of cases or it may be part of the autosomal dominant multiple endocrine neoplasia (MEN) type 2. While the 10-year survival rate is around 40–75%, for metastatic disease, it’s just below 20%.Case presentation: We report the case of ...

Trabecular bone score (TBS) evaluates bone microarchitecture by measuring the grey-level variations from lumbar spine dual-energy X-ray absorbtiometry (DXA) images. Bone mineral density (BMD) in various endocrinopathies might not be sufficient in assessing bone fragility, especially in patients with acromegaly (ACM) but also in thyrotoxicosis. The aim of our study was to evaluate bone quality and quantity by BMD and TBS in patients with acromegaly and thyrotoxicosis.<p cla...

Background: Diabetes mellitus is a metabolic disease associated with an increased risk of fracture, despite normal or increased bone mineral density (BMD), especially type 2 diabetes mellitus (T2DM). Trabecular bone score (TBS) is an imaging investigation that measures the grayscale variations on the lumbar spine performed on the DXA machine. The aim of this study was to evaluate the determinants associated with low BMD and TBS in patients with type 1 and type 2 diabetes melli...

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

Background: Active acromegaly is characterized by decreased insulin sensitivity (ISen). However, insulin secretion (ISec) may not increase satisfactorily to compensate for the low ISen.Aim: To assess ISen and ISec and to calculate disposition index (DI) using an intravenous glucose tolerance test (IVGTT) in patients with active acromegaly.Methods: Twelve patients (7 men, 5 women) with active acromegaly and 2 normal subjects (2 men)...

Introduction: The pituitary tumors which are considered pituitary incidentalomas are accidentally discovered at pituitary scan and they associate a lack of pituitary hyper-secretion. Opposite to what generally are considered for adrenal incidentalomas, the pituitary incidentalomas are more frequent with years of life.Aim: We analyzed the incidentaloma sizes related to decades of age.Material and method: This is a retrospective stud...